Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

For human researchers, it takes many years of work to discover new super-resolution microscopy techniques. The number of possible optical configurations of a microscope—for example, where to place ...

In biology, seeing can lead to understanding, and researchers in Professor Edward Boyden's lab at the McGovern Institute for Brain Research are committed to bringing life into sharper focus. With a ...

A new variant of expansion microscopy that is tailored for brain pathology samples reveals cells and structures that can’t be seen with other methods. Expansion microscopy is a way of achieving the ...

From overcoming classical optical limits to tracking single proteins in real time, super-resolution imaging continues to ...

A new microscopy method enables researchers to visualize the activity of the enzymes caspase-3 and alkaline phosphatase in various biological samples (Nat. Methods 2024, DOI: ...

Imagine building a traffic surveillance camera that could detect trouble-making cells speeding around in your brain before their cellular gang could commit "crimes." Most importantly, this camera ...

SIMIP enables high-resolution images rich in both chemical and spatial information. A quantum cascade laser (QCL) excites molecular vibrations while a spatial light modulator (SLM) generates striped ...

This article describes a six-inch wafer inspection microscope that provides automated, reproducible differential interference contrast (DIC) imaging, regardless of the user’s skill level. Wafer ...